ADAM and Eph: how Ephrin-signaling cells become detached.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16239135.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.
Medical subject headings
- ADAM Proteins
- Ephrin-A2
- Ephrin-A3
- Ephrin-A5
- Membrane Proteins