In vitro and in vivo two-photon luminescence imaging of single gold nanorods.
basic_science · Level V
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- Record sourced from PubMed, PMID 16239346.
- Also identified by PMC identifier 1276057.
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Abstract
Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a cos(4) dependence on the incident polarization. The TPL excitation spectrum can be superimposed onto the longitudinal plasmon band, indicating a plasmon-enhanced two-photon absorption cross section. The TPL signal from a single nanorod is 58 times that of the two-photon fluorescence signal from a single rhodamine molecule. The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels.
Medical subject headings
- Diagnostic Imaging
- Gold
- Luminescent Measurements