Resolution of EBV(+) CNS lymphoma with appearance of CSF EBV-specific T cells.
case_report · Level V
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Abstract
Current knowledge of Epstein-Barr virus (EBV)-specific T-cell responses in the cerebrospinal fluid (CSF) of patients with EBV-related lymphoproliferative disease (EBV-LPD) in the central nervous system (CNS) is very limited. Here, we present two recipients of hematopoietic stem cell transplants with EBV-LPD in the CNS. EBV-specific CD8(+) T lymphocytes were detected in CSF and peripheral blood using major histocompatibility complex (MHC) class I multimers loaded with EBV-derived peptides. The appearance of EBV-specific CD8(+) T cells in CSF and blood correlated with neurological improvement and disappearance of EBV-LPD. These observations suggest a role for EBV-specific CD8(+) T cells in the control of EBV-LPD in the CNS.
Medical subject headings
- Central Nervous System Neoplasms
- Epstein-Barr Virus Infections
- Hematopoietic Stem Cell Transplantation
- Herpesvirus 4, Human
- Lymphoma
- T-Lymphocytes