The proteasome: not just degrading anymore.
review · Level V
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Abstract
The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions.
Medical subject headings
- Promoter Regions, Genetic
- Proteasome Endopeptidase Complex
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins