An E-MAP of the ER.
basic_science · Level V
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Abstract
Genome-wide phenotype mapping has the potential to provide insights into gene function on an unprecedented scale. In this issue of Cell, Schuldiner et al.(2005) show that saturation epistasis analysis of genes implicated in the early secretory pathway in yeast provides a new strategy for uncovering functional relationships using high-throughput genomic data.
Medical subject headings
- Endoplasmic Reticulum
- Epistasis, Genetic
- Protein Interaction Mapping
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins