SUMOylation and PPARgamma: wrestling with inflammatory signaling.
basic_science · Level V
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Abstract
The molecular mechanisms whereby PPARgamma inhibits inflammatory gene expression in macrophages are poorly understood. In a recent Nature paper, provide a new model for trans-repression in which ligand-dependent SUMOylation of PPARgamma results in its recruitment to the promoters of inflammatory genes where it inhibits transcription by preventing clearance of corepressor complexes.
Medical subject headings
- Inflammation
- Nuclear Proteins
- PPAR gamma
- Repressor Proteins
- SUMO-1 Protein