Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16273102.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.
Medical subject headings
- CCR5 Receptor Antagonists
- Macaca
- Pyrazoles
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- Vagina
- Valine