Serum anticholinergic activity, white matter hyperintensities, and cognitive performance.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 16275844.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The authors investigated whether the cognitive impairments associated with white matter hyperintensities (WMH) in normal elderly subjects are exacerbated by any anticholinergic medications being taken by the subjects. Results showed serum anticholinergic activity (SAA) and WMH volume to have a synergistic interaction such that the cognitive decrements associated with increasing WMH volume were greatest in those older individuals in the highest quartile of the SAA distribution.
Medical subject headings
- Cerebral Infarction
- Cerebrovascular Disorders
- Cognition Disorders
- Muscarinic Antagonists