Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomalies.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 16275846.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Absence of the corpus callosum is often associated with cognitive deficits, autism, and epilepsy. Using a genomic microarray, the authors analyzed DNA from 25 patients with radiographically confirmed callosal anomalies and identified three patients with de novo copy number changes in chromosome regions 2q37, 6qter, and 8p. Chromosomal deletions and duplications may be a relatively common cause of cerebral malformations.
Medical subject headings
- Agenesis of Corpus Callosum
- DNA
- Genetic Predisposition to Disease
- Mutation
- Nervous System Malformations