Slugging it out: fine tuning the p53-PUMA death connection.
editorial · Level V
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- Record sourced from PubMed, PMID 16286002.
- Also identified by PMC identifier 4578637.
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Abstract
In response to DNA damage, the tumor suppressor p53 elicits a complex cellular response. In this issue of Cell, Wu et al. (2005) show that the transcription factor SLUG is induced by p53 and protects hematopoietic progenitor cells from apoptosis triggered by DNA damage. SLUG exerts this protective role by repressing Puma, a proapoptotic target of p53. PUMA is also a key coordinator of apoptosis mediated by both nuclear and cytoplasmic functions of p53 (Chi-puk et al., 2005).
Medical subject headings
- Apoptosis
- Transcription Factors
- Tumor Suppressor Protein p53
- Tumor Suppressor Proteins