Bio-sensing on a chip with compact discs and nanofibers.
other · Level V
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- Record sourced from PubMed, PMID 16286975.
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Abstract
This paper describes a novel, sensitive detection system for biomolecules (DNA and proteins etc.) that is integrated in a lab-on-a-chip utilizing optical compact discs (CDs) and bio-nanofibers. The new method comprises a microchannel containing CD grating that confines fragments of unique bacterial cellulose fibrils (BC), which have nanometre scale fibers and holes. A maximum of six times higher sensitivity to detect DNA was obtained with this CD and BC system compared to a conventional method. We also demonstrate an effective light-confining effect for biological application with the new method.
Medical subject headings
- Biosensing Techniques
- Coated Materials, Biocompatible
- Compact Disks
- DNA
- Lasers
- Nanostructures
- Spectrometry, Fluorescence