Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate.
basic_science · Level V
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- Record sourced from PubMed, PMID 1631087.
- Also identified by PMC identifier 402127.
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Abstract
The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these cells are grown in physiological concentrations of folate, the receptor increases the efficiency of vitamin uptake by 30-fold. We now show that PAM 212 cells, a mouse keratinocyte cell line, are unable to grow in 1 nM 5-methyltetrahydrofolate unless they express a functional folate receptor. These results suggest that under certain conditions, tissue cells in the body may depend on the folate receptor to obtain enough 5-methyltetrahydrofolate for growth.
Medical subject headings
- Carrier Proteins
- Receptors, Cell Surface
- Tetrahydrofolates