Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.
basic_science · Level V
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- Record sourced from PubMed, PMID 16311604.
- Also identified by PMC identifier 3018862.
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Abstract
We transplanted kidneys from alpha1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.
Medical subject headings
- Animals, Genetically Modified
- Graft Rejection
- Immune Tolerance
- Kidney Transplantation
- Transplantation, Heterologous