Paircoil2: improved prediction of coiled coils from sequence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16317077.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We introduce Paircoil2, a new version of the Paircoil program, which uses pairwise residue probabilities to detect coiled-coil motifs in protein sequence data. Paircoil2 achieves 98% sensitivity and 97% specificity on known coiled coils in leave-family-out cross-validation. It also shows superior performance compared with published methods in tests on proteins of known structure.
Medical subject headings
- Algorithms
- Models, Chemical
- Models, Molecular
- Sequence Analysis, Protein
- Software