Desperately seeking sugar: glial cells as hypoglycemia sensors.
Level V
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- Record sourced from PubMed, PMID 16322788.
- Also identified by PMC identifier 1297271.
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Abstract
A life-saving response to hypoglycemia requires rapid sensing of decreases in glycemia and consequent brisk glucagon secretion. Preceding studies have shown that mice lacking glucose transporter type 2 (GLUT2) lose this response. In this issue of the JCI, Marty et al. report that glucose sensing and consequent pancreatic glucagon secretion are restored by re-expression of GLUT2 in glial but not neuronal cells. A new, glucose-sensing role is ascribed to GLUT2-expressing glial cells.
Medical subject headings
- Hypoglycemia
- Neuroglia