Beta-arrestin goes nuclear.
review · Level V
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Abstract
Arrestins have important roles in the cytoplasm and at the plasma membrane, including the desensitization and internalization of G protein-coupled receptors (GPCRs). In this issue of Cell, Kang et al. (2005) provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters.
Medical subject headings
- Arrestins
- Cell Nucleus
- Gene Expression Regulation
- Receptors, G-Protein-Coupled