The battlefield of pluripotency.
editorial · Level V
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- Record sourced from PubMed, PMID 16325569.
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Abstract
How embryonic stem cells maintain the potential to differentiate into multiple cell lineages is still unclear. In this issue of Cell, Niwa et al. (2005) show that a duel between the transcription factors Oct3/4 and Cdx2 can restrict embryonic stem cells to either embryonic or placental fate. The vulnerability of lineage potential to transcriptional perturbation may reflect an essential feature of pluripotency.
Medical subject headings
- Cell Lineage
- Pluripotent Stem Cells