Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling.
basic_science · Level V
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Abstract
Osteoblasts influence bone mass by the amount of bone they synthesize and by regulating osteoclasts, the cells that degrade bone. In the December issue of Developmental Cell, Kieslinger et al. (2005) show that immature osteoblasts regulate expression of the osteoclast inhibitor, osteoprotegerin, through an early B cell factor and β-catenin signaling.
Medical subject headings
- Bone and Bones
- Glycoproteins
- Receptors, Cytoplasmic and Nuclear
- Receptors, Tumor Necrosis Factor
- beta Catenin