Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid.
cross_sectional · Level IV
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Abstract
The authors studied 40 epileptic patients treated with valproate and 40 healthy controls for at least 2 years. At the end of follow-up, 15 epileptic patients (37.5%) had development of obesity. They showed circulating leptin and insulin levels significantly higher and ghrelin and adiponectin levels significantly lower than those of patients who did not gain weight.
Medical subject headings
- Adiponectin
- Epilepsy
- Leptin
- Obesity
- Peptide Hormones
- Valproic Acid