Sequence-encoded self-assembly of multiple-nanocomponent arrays by 2D DNA scaffolding.
basic_science · Level V
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Abstract
Regular 2D arrays of multiple types of nanocomponents were constructed by self-assembly to DNA scaffolding with alternating rows of sequence-encoded hybridization sites. Different-sized Au particles coated with DNA complementary to one of the sites were bound to the scaffolding, producing alternating rows of the two nanocomponents with a 32-nm inter-row spacing. These results demonstrate the potential for using DNA to self-assemble complex arrays of components with nanometer-scale precision.
Medical subject headings
- Crystallization
- DNA
- In Situ Hybridization
- Nanostructures
- Oligonucleotide Array Sequence Analysis