PIDD: a switch hitter.
review · Level V
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- Record sourced from PubMed, PMID 16360026.
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Abstract
In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.
Medical subject headings
- Apoptosis
- Carrier Proteins
- DNA Damage