Under pressure: stromal fibroblasts change their ways.
editorial · Level V
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Abstract
In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression.
Medical subject headings
- Epithelial Cells
- Fibroblasts
- Mutation
- Stromal Cells
- Tumor Suppressor Protein p53