Does complete deficiency of muscle alpha actinin 3 alter functional capacity in elderly women? A preliminary report.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 16371478.
- Also identified by PMC identifier 2491941.
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Abstract
The sarcomeric protein alpha actinin 3 is localised to the Z line of fast fibres, which are responsible for generating forceful muscle contractions at high velocity. However, a substantial proportion of healthy humans are totally deficient in this protein as they are homozygous for a premature stop codon polymorphism (R577X) in the ACTN3 gene. The purpose of this preliminary study was to assess if the presence or absence of alpha actinin 3 influences the deleterious effects of ageing on muscle output and functional capacity.
Medical subject headings
- Actinin
- Aging
- Muscle, Skeletal