Fanconi anemia (cross)linked to DNA repair.
review · Level V
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- Record sourced from PubMed, PMID 16377561.
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Abstract
Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.
Medical subject headings
- DNA Helicases
- DNA Repair
- Fanconi Anemia
- Fanconi Anemia Complementation Group Proteins