Dopamine transporter imaging study in parkinsonism occurring in fragile X premutation carriers.
case_series · Level IV
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Abstract
The authors studied four patients with parkinsonism carrying the fragile X premutation using SPECT with ([23)I]FP-CIT. They found evidence of preserved presynaptic nigrostriatal function, suggesting that parkinsonism in the X fragile premutation might be related to postsynaptic dopaminergic changes or different neurotransmitter alterations.
Medical subject headings
- Brain
- Dopamine Plasma Membrane Transport Proteins
- Fragile X Syndrome
- Heterozygote
- Parkinson Disease