Minaprine in depression. A controlled trial with amitriptyline.
rct · Level II
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- Record sourced from PubMed, PMID 1638306.
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Abstract
Minaprine (200 mg daily, either once or divided b.d.) was compared with amitriptyline (25-50 mg t.d.s.) over six weeks in 144 patients with major depression. Significant reductions in HRSD scores at the end of six weeks' treatment were recorded with both dose regimes of minaprine and with amitriptyline, with no significant differences between them. There was a significantly greater incidence of drowsiness and dry mouth with amitriptyline than with minaprine.
Medical subject headings
- Antidepressive Agents
- Depressive Disorder
- Pyridazines