A missing sugar prevents glucose entry: a new twist on insulin secretion.
basic_science · Level V
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Abstract
The signaling pathway that regulates glucose-stimulated insulin secretion depends on glucose metabolism, which is itself controlled by glucokinase. In a recent issue of Cell, show that altering N-glycosylation of the GLUT2 glucose transporter prevents its anchoring and retention at the cell surface; this impairs glucose uptake and insulin secretion.
Medical subject headings
- Glucose
- Glucose Transporter Type 2
- Insulin