Autologous peripheral blood stem cell transplantation for POEMS syndrome.
case_series · Level IV
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- Record sourced from PubMed, PMID 16401856.
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Abstract
Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.
Medical subject headings
- Hematopoietic Stem Cell Transplantation
- Melphalan
- Myeloablative Agonists
- POEMS Syndrome