Adherence of human newborn infants' monocytes to matrix-bound fibronectin.
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Abstract
The localization of monocytes to sites of inflammation is mediated by interactions with extracellular matrix components including fibronectin, a nonimmune opsonin with binding sites for collagen, fibrin, heparin, and cell surfaces. This study demonstrates that newborn infants' monocytes bind to both gelatin (i.e., denatured collagen) and matrix-bound fibronectin to a degree comparable to that of adult-derived cells.
Medical subject headings
- Fibronectins
- Infant, Newborn
- Monocytes