Can modulating corticotropin releasing hormone receptors alter visceral sensitivity?
Level V
Where this comes from
- Record sourced from PubMed, PMID 16407379.
- Also identified by PMC identifier 1856495.
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Abstract
Activation of corticotropin releasing hormone (CRH) receptor 2 (CRH-R2) reduces visceral sensitivity induced by colorectal distension in conscious rats. This finding is relevant to the increased interest in the potential use of therapeutic agents that act on CRH receptors in the treatment of irritable bowel syndrome.
Medical subject headings
- Intestine, Large
- Receptors, Corticotropin-Releasing Hormone
- Stress, Psychological