Pathogens reWritE Rho's rules.
review · Level V
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- Record sourced from PubMed, PMID 16413475.
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Abstract
Many bacterial pathogens use a specialized "type III" secretion system to deliver virulence effector proteins into host mammalian cells. In this issue of Cell, Alto et al. (2006) describe a new family of effectors that share a WxxxE sequence motif. These effectors directly stimulate host signaling pathways by mimicking activated Ras-like cellular GTPases.
Medical subject headings
- Bacteria
- Bacterial Proteins
- Molecular Mimicry
- Signal Transduction
- ras Proteins