Protein sensors for membrane sterols.
review · Level V
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- Record sourced from PubMed, PMID 16413480.
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Abstract
Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.
Medical subject headings
- Cell Membrane
- Feedback, Physiological
- Membrane Proteins
- Sterols