Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA.
basic_science · Level V
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Abstract
Expression of a cloned dopamine transporter complementary DNA in COS cells allows these primate kidney cells to accumulate the parkinsonism-inducing neurotoxin metabolite MPP+ (1-methyl-4-phenylpyridinium) avidly, and MPP+ toxicity results. By documenting that the dopamine transporter can confer MPP+ sensitivity to nonneural cells, these results highlight the key role that this transporter could play in mechanisms underlying parkinsonism.
Medical subject headings
- 1-Methyl-4-phenylpyridinium
- Carrier Proteins
- DNA
- Kidney
- Membrane Glycoproteins
- Membrane Transport Proteins
- Parkinson Disease, Secondary