Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: three cases.

Perrinaud, Adeline; Jacobi, David; Machet, Marie-Christine; Grodet, Claire; Gruel, Yves; Machet, Laurent · J Am Acad Dermatol · 2006

case_report · Level V

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Abstract

Cutaneous side effects from heparin administration are rare and usually located at injection sites. We report 3 cases of intraepidermal hemorrhagic blisters occurring distant from sites of subcutaneous injections of heparin. A causative link is suggested by a temporal relationship between heparin introduction and onset of disease as well as exclusion of other causes, but the mechanism remains unknown.

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