Interleukin-18, neutrophils, and ANCA.
editorial · Level V
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Abstract
Hewins et al. show that IL-18 is expressed in the kidneys of patients with ANCA-associated glomerulonephritis, and that IL-18 primes neutrophils via p38 MAPK. These findings suggest a role for IL-18, including IL-18-induced T(H)1 polarization and IFN-gamma production, in the progression of ANCA disease.
Medical subject headings
- Antibodies, Antineutrophil Cytoplasmic
- Autoimmune Diseases
- Glomerulonephritis
- Interleukin-18
- Neutrophils