A greedy promoter controls malarial var-iations.
basic_science · Level V
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Abstract
Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encode variant surface antigens. In a recent paper in Nature, demonstrate that a construct carrying a transcriptionally active var promoter is sufficient to promote allelic exclusion of the parasite's endogenous var gene.
Medical subject headings
- Antigenic Variation
- Antigens, Protozoan
- Malaria, Falciparum
- Plasmodium falciparum
- Promoter Regions, Genetic
- Protozoan Proteins