REGgamma: a shortcut to destruction.
basic_science · Level V
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- Record sourced from PubMed, PMID 16439199.
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Abstract
Destruction of intact cellular proteins is largely orchestrated by ATP-dependent ubiquitination and subsequent degradation by the 26S proteasome. The REG-20S proteasome, however, only degrades short peptides. In this issue of Cell, challenge this notion by revealing that the proteasomal activator REGgamma directs degradation of the steroid receptor coactivator SRC-3 by the 20S proteasome in an ATP- and ubiquitin-independent manner.
Medical subject headings
- Acetyltransferases
- Autoantigens
- Oncogene Proteins
- Proteasome Endopeptidase Complex
- Trans-Activators