Methylglyoxal comes of AGE.
review · Level V
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Abstract
The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.
Medical subject headings
- Gene Expression Regulation
- Glycation End Products, Advanced
- Pyruvaldehyde