DNA double-strand break repair: a relentless hunt uncovers new prey.
basic_science · Level V
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Abstract
A major pathway for repair of DNA double-strand breaks is nonhomologous end-joining (NHEJ). In this issue of Cell, and report the discovery of a new NHEJ factor called Cernunnos-XLF. Both groups report that this protein is mutated in a rare inherited human syndrome characterized by severe immunodeficiency, developmental delay, and hypersensitivity to agents that cause DNA double-strand breaks.
Medical subject headings
- DNA Damage
- DNA Repair
- DNA-Binding Proteins