5. IgE, mast cells, basophils, and eosinophils.
review · Level V
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- Record sourced from PubMed, PMID 16455345.
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Abstract
IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment, becomes fixed to FcepsilonRI on the membranes of mast cells and basophils. Aggregation of receptor-bound IgE molecules on re-exposure to specific allergen results in the production of mediators that produce the allergic response. Principal among the cells drawn to sites of mediator release is the eosinophil.
Medical subject headings
- Basophils
- Eosinophils
- Hypersensitivity
- Immunoglobulin E
- Mast Cells