Early growth response-1 in cardiovascular pathobiology.
review · Level V
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Abstract
The immediate-early gene product and zinc finger transcription factor early growth response (Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes. This article reviews the amazing recent evidence implicating Egr-1 in atherosclerosis, intimal thickening after acute vascular injury, ischemic pathology, angiogenesis, allograft rejection, and cardiac hypertrophy.
Medical subject headings
- Atherosclerosis
- Cardiomegaly
- Early Growth Response Protein 1
- Graft Rejection
- Neovascularization, Physiologic