Certainly can't live without this: SIRT6.
Where this comes from
- Record sourced from PubMed, PMID 16459306.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Cellular metabolic rates might regulate aging by impinging on genomic stability through the DNA repair pathways. A new study published in Cell (Mostoslavsky et al., 2006) reports that deficiency in one of the mammalian Sir2 homologs, SIRT6, results in genome instability through the DNA base excision repair pathway and leads to aging-associated degenerative phenotypes.
Medical subject headings
- Aging
- DNA Repair
- Genomic Instability
- Phenotype
- Sirtuins