Is homocysteine an iron-dependent cardiovascular risk factor?
other · Level V
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- Record sourced from PubMed, PMID 16467888.
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Abstract
Recent studies of endothelial function suggest that adverse vascular effects of homocysteine are iron-dependent. Iron sucrose worsens and iron chelation eliminates homocysteine-associated decreases in flow-mediated dialation. There may be no vasculopathic effect of homocysteine without available reactive iron. Iron-dependent amplification of the vascular effects of homocysteine may be one of several mechanisms by which stored iron increases cardiac risk.
Medical subject headings
- Cardiovascular Diseases
- Endothelium, Vascular
- Homocysteine
- Iron