Rejuvenating exhausted T cells during chronic viral infection.
review · Level V
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Abstract
In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Virus Diseases