Organ dysfunction during sepsis.

Abstract

Multiple organ dysfunction syndrome is the commonest reason for sepsis-associated mortality. In the 40 years since it was first described understanding of its pathophysiology has improved, and novel methodologies for monitoring and severity of illness scoring have emerged. These, together with the development of systematic strategies for managing organ dysfunction in sepsis, and potentially effective new therapeutic interventions, should assist in reducing sepsis-associated mortality. These historical developments are discussed, and the reader is directed to these references for further guidance.