Pontine and cerebellar atrophy correlate with clinical disability in SCA2.
cross_sectional · Level IV
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Abstract
Spinocerebellar ataxia type 2 (SCA2) has protean manifestations, and a clinical marker of progression is needed. Although MRI is a promising tool, it is unclear whether the degree of atrophy shown on MRI is correlated with clinical dysfunction. Here the authors used high-resolution volumetric MRI analysis to show that cerebellar and pontine volumes specifically and closely correlate with functional staging scores.
Medical subject headings
- Cerebellum
- Magnetic Resonance Imaging
- Pons
- Spinocerebellar Ataxias