Formation of human prostate tissue from embryonic stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16489334.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Rodent models and immortalized or genetically modified cell lines are frequently used-but have limited utility-for studying human prostate development and maturation. Using rodent mesenchyme to establish reciprocal mesenchymal-epithelial cell interactions with human embryonic stem cells (hESCs), we generated human prostate tissue expressing prostate-specific antigen (PSA) within 8-12 weeks. This human prostate model shows species-conserved signalling mechanisms that could extend to integumental, gastrointestinal and genital tissues.
Medical subject headings
- Embryo, Mammalian
- Prostate
- Prostate-Specific Antigen
- Stem Cells