Chromatin remodeling by nucleosome disassembly in vitro.
basic_science · Level V
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- Record sourced from PubMed, PMID 16492771.
- Also identified by PMC identifier 1413907.
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Abstract
The RSC chromatin-remodeling complex completely disassembles a nucleosome in the presence of the histone chaperone Nap1 and ATP. Disassembly occurs in a stepwise manner, with the removal of H2A/H2B dimers, followed by the rest of the histones and the release of naked DNA. RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo.
Medical subject headings
- Chromatin Assembly and Disassembly
- Nucleosomes