Oxidative damage and aging: spotlight on mitochondria.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16510562.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Whereas free radical damage has been proposed as a key component in the tissue degeneration associated with aging, there has been little evidence that free radical damage limits life span in mammals. The current research shows that overexpression of the antioxidant enzyme catalase in mitochondria can extend mouse life span. These results highlight the importance of mitochondrial damage in aging and suggest that when targeted appropriately, boosting antioxidant defenses can increase mammalian life span.
Medical subject headings
- Aging
- Catalase
- Mitochondria
- Oxygen