PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.
review · Level V
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- Record sourced from PubMed, PMID 16511594.
- Also identified by PMC identifier 1386111.
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Abstract
Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
Medical subject headings
- Diabetes Mellitus
- Energy Metabolism
- Heart Diseases
- Liver
- Muscle, Skeletal
- Transcription Factors